The impact of carbamazepine crystallinity on carbamazepine-loaded microparticle formulations

Crystallinity plays a vital role in the pharmaceutical industry. It affects drug manufacturing, development processes, and stability of dosage forms. An objective this study was to measure analyze carbamazepine (CBZ) crystallinity before after formulation. Moreover, it intended determine extent which CBZ would affect loading, particle size, release from microparticles. The microparticles were prepared by encapsulating ethyl cellulose (EC) polymer using solvent evaporation method. EC used here as modifier polyvinyl alcohol (PVA) an aqueous phase stabilizer. Factorial design prepare microparticle formulations, including concentration, (dichloromethane, acetate), PVA concentrations factor, homogenization time, speed. calculated utilizing differential scanning calorimetry (DSC) thermal analysis. enthalpy CBZ. Enthalpy analyzed area under curve peak standard CBZ-loaded DSC ATR-FTIR assessed possible interaction between excipients microparticle. showed various changes rate had different effects on polymer. Statistically, all studied factors significantly affected formulation